(19)

(11)

EP 0 305 496 A1

(12)

(43) Date of publication: 08.03.1989 Bulletin 1989/10 (21) Application number: 88903090.0 (22) Date of filing: 17.03.1988

(51) International Patent Classification (IPC):  A61K 31/ 41( . ) A61K 31/ 535( . ) A61P 27/ 02( . ) C07D 417/ 00( . ) A61K 31/ 433( . ) A61P 25/ 02( . ) C07D 285/ 10( . ) C07D 417/ 12( . ) (86) International application number: PCT/US1988/000793 (87) International publication number: WO 1988/007044 (22.09.1988 Gazette 1988/21)

(84) Designated Contracting States: DE FR GB IT SE (30) Priority: 17.03.1987 US 19870026618 11.03.1988 US 19880167276 (71) Applicant: INSITE VISION, INC. Alameda, CA 94501 (US)	(72) Inventor: BUNDGAARD, Hans DK-2970 Horsholm (DK) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)