(19)

(11)

EP 0 308 424 A1

(12)

(43) Date of publication: 29.03.1989 Bulletin 1989/13 (21) Application number: 87903978.0 (22) Date of filing: 04.06.1987

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) C07K 1/ 20( . ) C07K 14/ 00( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) A61P 31/ 12( . ) C07K 1/ 22( . ) C07K 14/ 48( . ) C12N 15/ 09( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1987/001323 (87) International publication number: WO 1987/007617 (17.12.1987 Gazette 1987/28)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 05.06.1986 US 19860872332 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge, Massachusetts 02140 (US)	(72) Inventors: GURNEY, Mark, E. Chicago, IL 60615 (US) KNOPF, John, L. Acton, MA 01720 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)