(19)

(11)

EP 0 309 491 A1

(12)

(43) Date of publication: 05.04.1989 Bulletin 1989/14 (21) Application number: 88900934.0 (22) Date of filing: 23.12.1987

(51) International Patent Classification (IPC):  C12N 9/ 99( . ) A61P 31/ 12( . ) C07F 9/ 6533( . ) C07F 9/ 6558( . ) A61K 31/ 675( . ) A61P 43/ 00( . ) C07F 9/ 6544( . ) C07F 9/ 6561( . ) (86) International application number: PCT/US1987/003446 (87) International publication number: WO 1988/005438 (28.07.1988 Gazette 1988/17)

(84) Designated Contracting States: FR IT (30) Priority: 20.01.1987 US 19870005471 (71) Applicant: SRI INTERNATIONAL Menlo Park, California 94025 (US)	(72) Inventors: REIST, Elmer, J. Menlo Park, CA 94025 (US) STURM, Priscilla, A. Mountain View, CA 94040 (US) (74) Representative: Rinuy, Santarelli  14, avenue de la Grande Armée F-75017 Paris F-75017 Paris (FR)