(19)
(11) EP 0 312 963 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
19.12.1990 Bulletin 1990/51

(43) Date of publication A2:
26.04.1989 Bulletin 1989/17

(21) Application number: 88117254.8

(22) Date of filing: 17.10.1988
(51) International Patent Classification (IPC)4: C07K 1/14, C07K 3/08
(84) Designated Contracting States:
DE FR GB

(30) Priority: 21.10.1987 JP 265990/87

(71) Applicant: Kao Corporation
Chuo-ku Tokyo (JP)

(72) Inventors:
  • Matsunaga, Akira
    Wakayama-shi Wakayama-ken (JP)
  • Horinishi, Nobutaka
    Wakayama-shi Wakayama-ken (JP)
  • Wakatsuki, Junya
    Utsunomiya-shi Tochigi-ken (JP)
  • Imamura, Takashi
    Wakayama-shi Wakayama-ken (JP)
  • Kurosaki, Tomihiro
    Sennan-gun Osaka (JP)

(74) Representative: Wächtershäuser, Günter, Prof. Dr. 
Patentanwalt, Tal 29
80331 München
80331 München (DE)


(56) References cited: : 
   
       


    (54) Modification method for peptides and proteins


    (57) A peptide or protein is modified by reacting a phosphoric acid ester represented by the following general formula (I) with a peptide or protein:

    wherein R₁ means a linear or branched, C₁₋₃₆ alkyl or C₂₋₃₆ alkenyl group whose hydrogen atom or atoms may be substituted by the corresponding number of fluorine atom(s) or a phenyl group substituted by at least one linear or branched C₁₋₁₅ alkyl group, R₂ denotes a C₂₋₃ alkylene group, m stands for a number of 0-30, and M is a hydrogen atom, an alkali metal ion, an alkaline earth metal ion, an ammonium ion, an alkylamine residue or an alkanolamine residue.





    Search report