(19)

(11)

EP 0 321 505 A1

(12)

(43) Date of publication: 28.06.1989 Bulletin 1989/26 (21) Application number: 87907852.0 (22) Date of filing: 13.10.1987

(51) International Patent Classification (IPC):  A61K 31/ 19( . ) A61P 1/ 02( . ) A61K 31/ 215( . ) C07C 57/ 30( . ) (86) International application number: PCT/US1987/002587 (87) International publication number: WO 1988/003021 (05.05.1988 Gazette 1988/10)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 22.10.1986 US 19860921990 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: HALL, Charles, M. Kalamazoo, MI 49008 (US) JOHNSON, Herbert, G. Kalamazoo, MI 49007 (US) OFFENBACHER, Steven Stone Mountain, GA 30083 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)