(19)

(11)

EP 0 327 590 A1

(12)

(43) Date of publication: 16.08.1989 Bulletin 1989/33 (21) Application number: 87907864.0 (22) Date of filing: 19.10.1987

(51) International Patent Classification (IPC):  A61K 31/ 505( . ) A61P 37/ 00( . ) C07D 487/ 04( . ) A61P 31/ 04( . ) C07D 239/ 42( . ) (86) International application number: PCT/US1987/002727 (87) International publication number: WO 1988/003142 (05.05.1988 Gazette 1988/10)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.10.1986 US 19860923521 20.08.1987 US 19870086231 (71) Applicant: WARNER-LAMBERT COMPANY Ann Arbor, MI 48105 (US)	(72) Inventors: MALONE, Thomas, C. Canton, MI 48187 (US) SIRCAR, Jagadish, C. Ann Arbor, MI 48105 (US) (74) Representative: Mansmann, Ivo  Gödecke AG Patentwesen Mooswaldallee 1-9 D-79090 Freiburg D-79090 Freiburg (DE)