(19)

(11)

EP 0 329 770 A1

(12)

(43) Date of publication: 30.08.1989 Bulletin 1989/35 (21) Application number: 88908449.0 (22) Date of filing: 27.06.1988

(51) International Patent Classification (IPC):  C12N 9/ 00( . ) C12N 9/ 10( . ) C12N 15/ 53( . ) C12P 7/ 62( . ) C12N 9/ 04( . ) C12N 15/ 52( . ) C12N 15/ 54( . ) (86) International application number: PCT/US1988/002227 (87) International publication number: WO 1989/000202 (12.01.1989 Gazette 1989/02)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 29.06.1987 US 19870067695 (60) Divisional application: 01202302.4 / 1229123 (60) Divisional application: 95201427.2 / 0688865 (71) Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY Cambridge, MA 02139 (US)	(72) Inventors: PEOPLES, Oliver, P. Arlington, MA 02174 (US) SINSKEY, Anthony, J. Boston, MA 02115 (US) (74) Representative: Bassett, Richard Simon, et al  ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)