(19)

(11)

EP 0 335 955 A1

(12)

(43) Date of publication: 11.10.1989 Bulletin 1989/41 (21) Application number: 88909428.0 (22) Date of filing: 27.09.1988

(51) International Patent Classification (IPC):  A01K 61/ 00( . ) C12N 5/ 02( . ) C12R 1/ 91( . ) C12N 5/ 00( . ) C12N 5/ 07( . ) (86) International application number: PCT/US1988/003325 (87) International publication number: WO 1989/002919 (06.04.1989 Gazette 1989/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 28.09.1987 US 19870102127 (71) Applicant: LEE, Dosuk Brookline, MA 02167 (US)	(72) Inventor: LEE, Dosuk Brookline, MA 02167 (US) (74) Representative: Harrison, David Christopher, et al  MEWBURN ELLIS York House 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)