(19)
(11) EP 0 336 368 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
05.12.1990 Bulletin 1990/49

(43) Date of publication A2:
11.10.1989 Bulletin 1989/41

(21) Application number: 89105882.8

(22) Date of filing: 04.04.1989
(51) International Patent Classification (IPC)4: C07C 233/00, C07C 255/00, C07K 5/00, A61K 38/55, A61K 31/00, C07D 263/44, C07K 5/06, C07C 237/20, C07C 255/42
(84) Designated Contracting States:
BE CH DE ES FR GB IT LI

(30) Priority: 04.04.1988 JP 83632/88

(71) Applicant: KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA
Kita-ku Osaka-shi Osaka-fu 530 (JP)

(72) Inventors:
  • Inoue, Kenji
    Kako-gun Hyogo (JP)
  • Matsumoto, Mitsunori
    Nakatsu-shi Oita (JP)
  • Takahashi, Satomi
    Kobe-shi Hyogo (JP)

(74) Representative: VOSSIUS & PARTNER 
Postfach 86 07 67
81634 München
81634 München (DE)


(56) References cited: : 
   
       


    (54) N2-(1-carboxy-3-phenylpropyl)-L-lysine derivative and process of producing lysinopril using the compound


    (57) An N²-(1-substituted-3-phenylpropyl)-L-lysine derivative is disclosed and is represented by formula (I)

    wherein R¹ represents an acyl type or urethane type protective group; R² represents a hydrogen atom, an alkyl group, or an aralkyl group. X represents a cyano (CN) group or an aminocarbonyl (CONH₂) group; and the mark * represents the (S) configuration of theasymmetric carbon atom.





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