(19)

(11)

EP 0 336 960 A1

(12)

(43) Date of publication: 18.10.1989 Bulletin 1989/42 (21) Application number: 88910286.0 (22) Date of filing: 13.10.1988

(51) International Patent Classification (IPC):  A61K 31/ 195( . ) A61K 31/ 70( . ) (86) International application number: PCT/US1988/003591 (87) International publication number: WO 1989/004165 (18.05.1989 Gazette 1989/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI NL SE (30) Priority: 19.10.1987 US 19870109597 01.09.1988 US 19880239303 (71) Applicants: HAKLITCH, Joseph A. Bellflower, CA 90706 (US) NAITO, Albert T. Costa Mesa, CA 92626 (US)	(72) Inventors: HAKLITCH, Joseph A. Bellflower, CA 90706 (US) NAITO, Albert T. Costa Mesa, CA 92626 (US) (74) Representative: Jones, Colin, et al  W.P. THOMPSON & CO. Coopers Building Church Street Liverpool L1 3AB Liverpool L1 3AB (GB)