(19)

(11)

EP 0 341 303 A1

(12)

(43) Date of publication: 15.11.1989 Bulletin 1989/46 (21) Application number: 89900512.0 (22) Date of filing: 17.11.1988

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 49/ 00( . ) C07K 16/ 28( . ) C12N 5/ 10( . ) C12P 21/ 08( . ) G01N 33/ 577( . ) C12R 1/ 91( . ) A61K 39/ 395( . ) A61P 35/ 00( . ) C07K 16/ 30( . ) C12N 15/ 02( . ) G01N 33/ 566( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1988/004118 (87) International publication number: WO 1989/005155 (15.06.1989 Gazette 1989/13)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 19.11.1987 US 19870123045 (71) Applicant: SCRIPPS CLINIC AND RESEARCH FOUNDATION La Jolla California 92037-1093 (US)	(72) Inventor: CHERESH, David, A. San Diego, CA 92117 (US) (74) Representative: Fisher, Adrian John, et al  CARPMAELS & RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)