(19)

(11)

EP 0 341 304 A1

(12)

(43) Date of publication: 15.11.1989 Bulletin 1989/46 (21) Application number: 89900542.0 (22) Date of filing: 23.11.1988

(51) International Patent Classification (IPC):  C12N 15/ 00( . ) A61K 39/ 395( . ) C07K 14/ 415( . ) C07K 14/ 495( . ) C07K 14/ 525( . ) C07K 14/ 535( . ) C07K 14/ 545( . ) C07K 16/ 00( . ) C12P 21/ 02( . ) A61K 38/ 00( . ) A61P 35/ 00( . ) C07K 14/ 42( . ) C07K 14/ 52( . ) C07K 14/ 53( . ) C07K 14/ 54( . ) C07K 14/ 55( . ) C07K 19/ 00( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1988/004238 (87) International publication number: WO 1989/004839 (01.06.1989 Gazette 1989/12)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 24.11.1987 US 19870124735 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge, MA 02140 (US)	(72) Inventors: BROWN, Eugene, L. Newton Highlands, MA 02161 (US) JONES, Simon Brookline, MA 02146 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)