(19)

(11)

EP 0 342 206 A1

(12)

(43) Date of publication: 23.11.1989 Bulletin 1989/47 (21) Application number: 88902985.0 (22) Date of filing: 11.01.1988

(51) International Patent Classification (IPC):  C12N 5/ 10( . ) A61P 7/ 00( . ) C07K 1/ 20( . ) C07K 14/ 52( . ) C12P 21/ 02( . ) C12R 1/ 865( . ) A61K 38/ 00( . ) A61P 37/ 00( . ) C07K 14/ 00( . ) C07K 14/ 54( . ) C12R 1/ 19( . ) (86) International application number: PCT/US1988/000011 (87) International publication number: WO 1988/005469 (28.07.1988 Gazette 1988/17)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 20.01.1987 US 19870004466 (71) Applicant: IMMUNEX CORPORATION Seattle WA 98102 (US)	(72) Inventors: ANDERSON, Dirk, M. Seattle, WA 98133 (US) COSMAN, David, J. Seattle, WA 98102 (US) PRICE, Virginia, L. Seattle, WA 98102 (US) (74) Representative: Minoja, Fabrizio  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milano I-20122 Milano (IT)