(19)

(11)

EP 0 343 231 A1

(12)

(43) Date of publication: 29.11.1989 Bulletin 1989/48 (21) Application number: 89900706.0 (22) Date of filing: 02.11.1988

(51) International Patent Classification (IPC):  A61K 38/ 46( . ) C12N 1/ 19( . ) C12N 15/ 09( . ) C12R 1/ 84( . ) A61P 31/ 04( . ) C12N 9/ 36( . ) C12N 15/ 81( . ) (86) International application number: PCT/US1988/003907 (87) International publication number: WO 1989/004320 (18.05.1989 Gazette 1989/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 02.11.1987 US 19870115940 (71) Applicant: THE SALK INSTITUTE BIOTECHNOLOGY INDUSTRIAL ASSOCIATES, INC. La Jolla, CA 92037 (US)

(72) Inventors: DIGAN, Mary, Ellen San Diego, CA 92107 (US) HARPOLD, Michael, Miller San Diego, CA 92102 (US) LAIR, Stephen, Vernon Escondido, CA 92025 (US) THILL, Gregory, Patrick San Diego, CA 92111 (US) SIEGEL, Robert, Steven San Diego, CA 92117 (US) ELLIS, Steven, Bradley San Diego, CA 92129 (US) WILLIAMS, Mark, Edward Carlsbad, CA 92009 (US) (74) Representative: Bizley, Richard Edward, et al  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)