(19)

(11)

EP 0 344 211 A1

(12)

(43) Date of publication: 06.12.1989 Bulletin 1989/49 (21) Application number: 88902682.0 (22) Date of filing: 19.02.1988

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) A61K 39/ 42( . ) C12N 5/ 10( . ) C12N 15/ 06( . ) A61K 38/ 00( . ) C12R 1/ 91( . ) A61K 39/ 395( . ) C07K 16/ 42( . ) C12N 5/ 18( . ) C12P 21/ 08( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1988/000512 (87) International publication number: WO 1988/006040 (25.08.1988 Gazette 1988/19)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 20.02.1987 US 19870016807 17.02.1988 US 19880156691 (71) Applicant: IMCLONE SYSTEMS, INC. New York, NY 10014 (US)	(72) Inventors: COLUCCI, Giuseppe New York, NY 10000 (US) WAKSAL, Samuel, D. New York, NY 10000 (US) (74) Representative: Ahner, Francis  CABINET REGIMBEAU 26, avenue Kléber F-75116 Paris F-75116 Paris (FR)