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(11)

EP 0 344 234 A1

(12)

(43) Date of publication: 06.12.1989 Bulletin 1989/49 (21) Application number: 88908721.0 (22) Date of filing: 16.09.1988

(51) International Patent Classification (IPC):  C07K 9/ 00( . ) A61K 38/ 00( . ) C12P 21/ 04( . ) (86) International application number: PCT/GB1988/000752 (87) International publication number: WO 1989/002441 (23.03.1989 Gazette 1989/07)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 19.09.1987 GB 19870022090 09.12.1987 GB 19870028809 13.02.1988 GB 19880003353 (71) Applicant: BEECHAM GROUP PLC Brentford Middlesex TW8 9BD (GB)

(72) Inventors: ATHALYE, Medha Beecham Pharmaceuticals Betchworth Surrey RH3 7AJ (GB) ELSON, Anna Beecham Pharmaceuticals Betchworth Surrey RH3 7AJ (GB) GILPIN, Martin, Leonard Beecham Pharmaceuticals Betchworth Surrey RH3 7AJ (GB) JEFFRIES, Leonard, Richard Vallsala Javea (ES) (74) Representative: West, Vivien, et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)