TREATMENT OF MALIGNANT TUMORS WITH 8-CHLOROADENOSINE 3',5'-CYCLIC PHOSPHATE, 8-AMINOADENOSINE 3',5'-CYCLIC PHOSPHATE AND PREPARATION THEREOF - Patent 0346400

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EP 0 346 400 A1

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(43)	Date of publication:
	20.12.1989 Bulletin 1989/51

(21)	Application number: 88905052.0

(22)	Date of filing: 20.04.1988

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International Patent Classification (IPC):

C07D 473/ 34^{( . )}
A61K 31/ 7042^{( . )}
A61K 31/ 7076^{( . )}
C07H 19/ 16^{( . )}

A61K 31/ 70^{( . )}
A61K 31/ 7052^{( . )}
A61P 35/ 00^{( . )}
C07H 19/ 20^{( . )}

(86)	International application number:
	PCT/US1988/001217

(87)	International publication number:
	WO 1989/005648 (29.06.1989 Gazette 1989/14)

(84)	Designated Contracting States:
	AT BE CH DE FR GB IT LI LU NL SE

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Priority:

21.12.1987 US 19870136407
11.04.1988 US 19880180070

(60)	Divisional application:
	92106624.7 / 0499291

(71)	Applicant: NUCLEIC ACID RESEARCH INSTITUTE
	Costa Mesa, CA 92626 (US)

(72)	Inventors:
	ROBINS, Roland, K. Irvine, CA 92715 (US) REVANKAR, Ganapathi, R. Irvine, CA 92714 (US) CHANG, Yu-an Costa Mesa, CA 92626 (US)

(74)	Representative: Goldin, Douglas Michael
	J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)

(54)	TREATMENT OF MALIGNANT TUMORS WITH 8-CHLOROADENOSINE 3',5'-CYCLIC PHOSPHATE, 8-AMINOADENOSINE 3',5'-CYCLIC PHOSPHATE AND PREPARATION THEREOF