(19)

(11)

EP 0 348 460 A1

(12)

(43) Date of publication: 03.01.1990 Bulletin 1990/01 (21) Application number: 88910347.0 (22) Date of filing: 10.11.1988

(51) International Patent Classification (IPC):  C07D 209/ 72( . ) C07D 487/ 08( . ) C07D 401/ 06( . ) (86) International application number: PCT/US1988/003924 (87) International publication number: WO 1989/004311 (18.05.1989 Gazette 1989/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 12.11.1987 US 19870119520 (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)	(72) Inventors: ABOU-GHARBIA, Magid, A. Glen Mills, PA 19342 (US) PATEL, Usha, R. Brookfield, CT 06804 (US) (74) Representative: Connelly, Michael John, et al  John Wyeth & Brother Limited Huntercombe Lane South Taplow Maidenhead Berkshire, SL6 0PH Maidenhead Berkshire, SL6 0PH (GB)