(19)

(11)

EP 0 349 594 A1

(12)

(43) Date of publication: 10.01.1990 Bulletin 1990/02 (21) Application number: 88904294.0 (22) Date of filing: 02.03.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 01( . ) C07K 14/ 10( . ) C07K 14/ 18( . ) C12N 7/ 00( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) C07K 14/ 00( . ) C07K 14/ 02( . ) C07K 14/ 11( . ) C07K 19/ 00( . ) C12N 15/ 866( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1988/000631 (87) International publication number: WO 1988/007082 (22.09.1988 Gazette 1988/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 16.03.1987 US 19870026498 16.03.1987 US 19870026499 08.02.1988 US 19880153736 (71) Applicant: AMERICAN BIOGENETIC SCIENCES, INC. Copiague, NY 11726 (US)	(72) Inventors: FRASER, Malcolm, J. South Bend, IN 46615 (US) ROSEN, Elliot, D. South Bend, IN 46617 (US) PLOPLIS, Victoria, A. South Bend, IN 46615 (US) (74) Representative: Warcoin, Jacques, et al  Cabinet Régimbeau, 26, avenue Kléber F-75116 Paris F-75116 Paris (FR)