(19)

(11)

EP 0 349 598 A1

(12)

(43) Date of publication: 10.01.1990 Bulletin 1990/02 (21) Application number: 88904734.0 (22) Date of filing: 11.03.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 85( . ) C12N 5/ 10( . ) (86) International application number: PCT/US1988/000680 (87) International publication number: WO 1988/007083 (22.09.1988 Gazette 1988/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 13.03.1987 US 19870025461 (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventor: DRAPER, Kenneth, G. Madison, NJ 07940 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)