Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same

(19)

(11)

EP 0 350 221 A3

(12)	EUROPEAN PATENT APPLICATION

(88)	Date of publication A3:
	12.09.1990 Bulletin 1990/37

(43)	Date of publication A2:
	10.01.1990 Bulletin 1990/02

(21)	Application number: 89306693.6

(22)	Date of filing: 30.06.1989

(51)	International Patent Classification (IPC)⁵: C07K 5/10, A61K 38/22

(84)	Designated Contracting States:
	AT BE CH DE ES FR GB GR IT LI LU NL SE

(30)

Priority:

30.06.1988 CA 570874

(71)	Applicant: Astra Aktiebolag
	151 85 Södertälje (SE)

(72)	Inventor:
	Schiller, Peter W. Montreal Quebec H3G 2A4 (CA)

(74)	Representative: Linderoth, Margareta et al
	ASTRA AB, Patent Department 151 85 Södertälje 151 85 Södertälje (SE)

(56)

References cited: :

(54)	Dermorphin analogs, their methods of preparation, pharmaceutical compositions, and methods of therapeutic treatment using the same

(57) Peptides are provided which are suitable for the treatment of pain and gastro-intestinal disorders, such as diarrhea, and are represented by the structure:

where values for the substituents and n are disclosed herein. Methods for preparing these peptides by solution and solid phase syntheses are also provided. Pharmaceutical compositions utilizing these peptides in a pharmaceutically effective amount and methods of treatment using them are provided.

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