(19)

(11)

EP 0 351 427 A1

(12)

(43) Date of publication: 24.01.1990 Bulletin 1990/04 (21) Application number: 88910079.0 (22) Date of filing: 25.11.1988

(51) International Patent Classification (IPC):  C12N 1/ 21( . ) C12P 21/ 00( . ) C12N 15/ 75( . ) C12R 1/ 125( . ) (86) International application number: PCT/GB1988/001026 (87) International publication number: WO 1989/004866 (01.06.1989 Gazette 1989/12)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 27.11.1987 GB 19870027772 (71) Applicant: CELLTECH LIMITED Slough Berkshire SL1 4EN (GB)	(72) Inventor: MOUNTAIN, Andrew Wokingham Berkshire RG11 3DU (GB) (74) Representative: Hallybone, Huw George, et al  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)