(19)
(11) EP 0 356 385 A3

(12) EUROPEAN PATENT APPLICATION

(88) Date of publication A3:
01.08.1990 Bulletin 1990/31

(43) Date of publication A2:
28.02.1990 Bulletin 1990/09

(21) Application number: 89810595.2

(22) Date of filing: 08.08.1989
(51) International Patent Classification (IPC)5C07D 277/64, C07D 263/56, A61K 31/425, A61K 31/42
(84) Designated Contracting States:
AT BE CH DE ES FR GB GR IT LI LU NL SE

(30) Priority: 17.08.1988 GB 8819545

(71) Applicant: CIBA-GEIGY AG
4002 Basel (CH)

(72) Inventor:
  • Rao, Vittal Ramachandra
    Goregaon (IN)


(56) References cited: : 
   
       


    (54) New benzazole derivatives, processes for their preparation and pharmaceutical preparations containing such compounds and the use thereof


    (57) The invention relates to new benzazole derivatives of the formula I

    wherein X is oxygen or sulphur, R₁ is lower alkyl, lower alkenyl or cycloalkyl, optionally substituted, R₂ and R₃ independently of one another are each hydrogen, lower alkyl or cycloalkyl radicals or taken together are a substituted or unsubstituted bivalent hydrocarbon residue of aliphatic character in which the carbon atoms of the chain may be interrupted by a heteroatom, R₄ is either a group

    wherein R₅ and R₆ independently of one another are each hydrogen, lower alkyl or cycloalkyl radicals, optionally substituted, or taken together R₅ and R₆ are a substituted or unsubstituted bivalent hydrocarbon residue of aliphatic character in which the carbon atoms of the chain may be interrupted by a heteroatom, or, R₄ is a group

    where R₇ is a lower alkyl group, and their salts and N-oxides. The products are useful as anthelmintic effective agents. The products can be prepared to methods known per se.





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