(19)

(11)

EP 0 358 665 A1

(12)

(43) Date of publication: 21.03.1990 Bulletin 1990/12 (21) Application number: 88903795.0 (22) Date of filing: 15.04.1988

(51) International Patent Classification (IPC):  A61K 31/ 415( . ) C07D 233/ 78( . ) A61K 31/ 4166( . ) (86) International application number: PCT/EP1988/000318 (87) International publication number: WO 1988/008421 (03.11.1988 Gazette 1988/24)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 23.04.1987 IT 19870020229 (71) Applicant: L.B.S. S.r.l. LABORATORIO BIOCHIMICO SPERIMENTALE I-50055 Lastra a Signa (Firenze) (IT)	(72) Inventor: MAZZONI, Lucia I-50125 Firenze (IT) (74) Representative: Minoja, Fabrizio  Studio Consulenza Brevettuale, Via Rossini, 8 I-20122 Milano I-20122 Milano (IT)