(19)

(11)

EP 0 362 284 A1

(12)

(43) Date of publication: 11.04.1990 Bulletin 1990/15 (21) Application number: 88905482.0 (22) Date of filing: 16.05.1988

(51) International Patent Classification (IPC):  G01N 33/ 543( . ) (86) International application number: PCT/US1988/001565 (87) International publication number: WO 1988/008978 (17.11.1988 Gazette 1988/25)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 14.05.1987 US 19870049375 (71) Applicant: THE MCLEAN HOSPITAL CORPORATION Belmont, MA 02178 (US)	(72) Inventor: FLEMING, Nigel Cambridge, MA 02140 (US) (74) Representative: Sheard, Andrew Gregory  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)