(19)

(11)

EP 0 364 481 A1

(12)

(43) Date of publication: 25.04.1990 Bulletin 1990/17 (21) Application number: 88905578.0 (22) Date of filing: 15.06.1988

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 39/ 395( . ) A61P 13/ 02( . ) A61P 17/ 00( . ) C07K 1/ 16( . ) C07K 1/ 20( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C12N 5/ 00( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) C12R 1/ 91( . ) A61K 38/ 00( . ) A61P 9/ 14( . ) A61P 15/ 00( . ) A61P 43/ 00( . ) C07K 1/ 18( . ) C07K 1/ 22( . ) C07K 14/ 50( . ) C07K 16/ 22( . ) C12N 5/ 06( . ) C12P 21/ 02( . ) G01N 33/ 68( . ) (86) International application number: PCT/AU1988/000191 (87) International publication number: WO 1988/010269 (29.12.1988 Gazette 1988/28)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 18.06.1987 AU 19870002579 (71) Applicant: MONASH UNIVERSITY Clayton Victoria 3168 (AU)	(72) Inventors: HEARN, Milton, Thomas, William Balwyn, VIC 3103 (AU) BERTOLINI, Joseph 500 Flinders Street Melbourne, VIC 3000 (AU) GUTHRIDGE, Mark, Andrew Endeavour Hills, VIC 3802 (AU) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)