(19)

(11)

EP 0 364 493 A1

(12)

(43) Date of publication: 25.04.1990 Bulletin 1990/17 (21) Application number: 88906552.0 (22) Date of filing: 11.07.1988

(51) International Patent Classification (IPC):  C12N 9/ 99( . ) A61K 38/ 43( . ) A61P 9/ 12( . ) C07C 65/ 24( . ) C07C 235/ 16( . ) C07D 209/ 08( . ) C07D 215/ 14( . ) C07F 7/ 18( . ) C07K 5/ 06( . ) C07K 14/ 81( . ) A61K 31/ 16( . ) A61K 38/ 55( . ) C07C 65/ 21( . ) C07C 69/ 92( . ) C07C 323/ 12( . ) C07D 213/ 81( . ) C07D 263/ 06( . ) C07K 5/ 02( . ) C07K 7/ 02( . ) (86) International application number: PCT/US1988/002255 (87) International publication number: WO 1989/001488 (23.02.1989 Gazette 1989/05)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 07.08.1987 US 19870083614 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventor: TEN BRINK, Ruth, E. Richland, MI 49083 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)