(19)

(11)

EP 0 365 568 A1

(12)

(43) Date of publication: 02.05.1990 Bulletin 1990/18 (21) Application number: 88905725.0 (22) Date of filing: 09.06.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 7/ 02( . ) C07K 14/ 435( . ) C12N 5/ 10( . ) C12P 21/ 00( . ) A61K 38/ 00( . ) C07K 14/ 00( . ) C07K 14/ 745( . ) C12N 9/ 72( . ) C12R 1/ 91( . ) (86) International application number: PCT/DK1988/000089 (87) International publication number: WO 1988/009811 (15.12.1988 Gazette 1988/27)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 12.06.1987 DK 19870002990 (71) Applicant: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK)	(72) Inventors: NEX,Bjorn DK-2860 S borg (DK) ESPER, Boel DK-2840 Holte (DK) (74) Representative: Brown, John David  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)