| (19) |
 |
|
(11) |
EP 0 366 451 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
15.01.1992 Bulletin 1992/03 |
| (43) |
Date of publication A2: |
|
02.05.1990 Bulletin 1990/18 |
| (22) |
Date of filing: 25.10.1989 |
|
|
| (84) |
Designated Contracting States: |
|
AT BE CH DE ES FR GB GR IT LI LU NL SE |
| (30) |
Priority: |
26.10.1988 US 262760
|
| (71) |
Applicant: ORTHO PHARMACEUTICAL CORPORATION |
|
Raritan
New Jersey 08869-0602 (US) |
|
| (72) |
Inventor: |
|
- Lau, Catherine Y.
Unionville
Ontario, M3L 246 (CA)
|
| (74) |
Representative: Fisher, Adrian John et al |
|
CARPMAELS & RANSFORD
43 Bloomsbury Square
London WC1A 2RA
London WC1A 2RA (GB) |
|
| |
|
| (54) |
The use of oxidized polyamines, especially NN'-Bis-(3-propionaldehyde)-1-4-diaminobutane
(sperminedialdehyde) as immunosuppressive agents |
(57) Oxidized polyamines of the Formula:
OCH - ALK¹ - NR² - CH₂ - ALK² - CH₂ - NR² - Z
wherein
ALK¹ is independently alkylene;
R² is independently hydrogen or -CH₂R³;
R³ is independently alkyl;
ALK² is alkylene;
Z is H or ALK¹ -CHO;
and their acid addition salts are disclosed as immunosuppressive agents.