(19)

(11)

EP 0 366 707 A1

(12)

(43) Date of publication: 09.05.1990 Bulletin 1990/19 (21) Application number: 88906254.0 (22) Date of filing: 05.05.1988

(51) International Patent Classification (IPC):  A61K 51/ 10( . ) A61K 38/ 00( . ) C07K 16/ 30( . ) (86) International application number: PCT/US1988/001511 (87) International publication number: WO 1988/008854 (17.11.1988 Gazette 1988/25)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 06.05.1987 US 19870047192 (71) Applicants: OOSTERWIJK, Egbert New York, NY 10028 (US) WARNAAR, Sven O NL-2333 CC Leiden (NL)	(72) Inventors: OOSTERWIJK, Egbert New York, NY 10028 (US) WARNAAR, Sven O NL-2333 CC Leiden (NL) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)