PROTEASE-DEFICIENT GRAM-POSITIVE BACTERIA AND THEIR USE AS HOST ORGANISMS FOR THE PRODUCTION OF RECOMBINANT PRODUCTS

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EP 0 370 103 A1

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(43)	Date of publication:
	30.05.1990 Bulletin 1990/22

(21)	Application number: 89906977.0

(22)	Date of filing: 14.03.1989

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International Patent Classification (IPC):

C12N 1/ 20^{( . )}
C12N 15/ 75^{( . )}
C12Q 1/ 68^{( . )}
C12R 1/ 125^{( . )}

C12N 9/ 56^{( . )}
C12Q 1/ 37^{( . )}
C12R 1/ 07^{( . )}
C12R 1/ 445^{( . )}

(86)	International application number:
	PCT/US1989/001056

(87)	International publication number:
	WO 1989/010976 (16.11.1989 Gazette 1989/27)

(84)	Designated Contracting States:
	AT BE CH DE FR GB IT LI LU NL SE

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Priority:

05.05.1988 US 19880190483

(71)	Applicant: THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC.
	New York NY 10016 (US)

(72)	Inventors:
	BLACKBURN, Peter New York, NY 10036 (US) LONETTO, Michael, Arthur Brooklyn, NY 11238 (US) CHANG, Edward, L. Green Lawn, NY 11740 (US) POLAK, June Brooklyn, NY 11201 (US)

(74)	Representative: Lucas, Brian Ronald
	Lucas & Co. 135 Westhall Road Warlingham Surrey CR6 9HJ Warlingham Surrey CR6 9HJ (GB)

(54)	PROTEASE-DEFICIENT GRAM-POSITIVE BACTERIA AND THEIR USE AS HOST ORGANISMS FOR THE PRODUCTION OF RECOMBINANT PRODUCTS