(19)

(11)

EP 0 372 002 A1

(12)

(43) Date of publication: 13.06.1990 Bulletin 1990/24 (21) Application number: 88908882.0 (22) Date of filing: 19.09.1988

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) C07H 21/ 04( . ) C07H 21/ 00( . ) C12N 9/ 08( . ) (86) International application number: PCT/US1988/003213 (87) International publication number: WO 1989/002932 (06.04.1989 Gazette 1989/08)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 02.10.1987 US 19870103978 (71) Applicant: CETUS CORPORATION Emeryville California 94608 (US)	(72) Inventors: LEVENSON, Corey Oakland, CA 94610 (US) CHANG, Chu-An El Cerrito, CA 94530 (US) OAKES, Fred, T. Rochester, NY 14617 (US) (74) Representative: Bizley, Richard Edward  BOULT, WADE & TENNANT 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)