(19)

(11)

EP 0 372 056 A1

(12)

(43) Date of publication: 13.06.1990 Bulletin 1990/24 (21) Application number: 89906530.0 (22) Date of filing: 02.05.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 9/ 127( . ) A61K 47/ 48( . ) C07K 14/ 705( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) A61K 9/ 107( . ) A61K 39/ 00( . ) C07K 14/ 00( . ) C07K 16/ 28( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1989/001858 (87) International publication number: WO 1989/010938 (16.11.1989 Gazette 1989/27)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 04.05.1988 US 19880189971 31.08.1988 US 19880238926 (71) Applicant: DANA FARBER CANCER INSTITUTE Boston Massachusetts 02115 (US)	(72) Inventors: DUSTIN, Michael, L. Boston, MA 02215 (US) SPRINGER, Timothy, A. Chestnut Hill, MA 02167 (US) (74) Representative: Sheard, Andrew Gregory, et al  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)