(19)

(11)

EP 0 374 140 A1

(12)

(43) Date of publication: 27.06.1990 Bulletin 1990/26 (21) Application number: 87905892.0 (22) Date of filing: 28.08.1987

(51) International Patent Classification (IPC):  A61M 5/ 00( . ) G01N 33/ 483( . ) A61L 29/ 00( . ) (86) International application number: PCT/US1987/002175 (87) International publication number: WO 1989/001794 (09.03.1989 Gazette 1989/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (71) Applicant: THE REGENTS OF THE UNIVERSITY OF MINNESOTA Minneapolis, Minnesota 55455 (US)	(72) Inventors: DORMAN, Frank, D. Minneapolis, MN 55422 (US) WIGNESS, Bruce, D. Minneapolis, MN 55404 (US) (74) Representative: Plougmann, Ole, et al  c/o Plougmann & Vingtoft A/S, Sankt Annae Plads 11, P.O. Box 3007 DK-1021 Copenhagen K DK-1021 Copenhagen K (DK)