(19)

(11)

EP 0 375 698 A1

(12)

(43) Date of publication: 04.07.1990 Bulletin 1990/27 (21) Application number: 88906775.0 (22) Date of filing: 27.06.1988

(51) International Patent Classification (IPC):  A61B 3/ 13( . ) A61B 3/ 12( . ) G02B 27/ 64( . ) A61B 3/ 117( . ) A61B 3/ 125( . ) (86) International application number: PCT/US1988/002228 (87) International publication number: WO 1990/000028 (11.01.1990 Gazette 1990/02)

(84) Designated Contracting States: CH DE FR GB IT LI (71) Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK New York, New York 10027 (US)	(72) Inventor: KOESTER, Charles, J. Glen Rock, NJ 07452 (US) (74) Representative: Henkel, Feiler, Hänzel & Partner  Möhlstrasse 37 D-81675 München D-81675 München (DE)