(19)

(11)

EP 0 375 740 A1

(12)

(43) Date of publication: 04.07.1990 Bulletin 1990/27 (21) Application number: 88908587.0 (22) Date of filing: 01.09.1988

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) C07K 1/ 02( . ) C07K 7/ 08( . ) C07K 14/ 81( . ) C07K 16/ 38( . ) A61K 39/ 00( . ) C07K 1/ 113( . ) C07K 14/ 00( . ) C07K 16/ 00( . ) C07K 19/ 00( . ) (86) International application number: PCT/US1988/003033 (87) International publication number: WO 1989/001943 (09.03.1989 Gazette 1989/06)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 04.09.1987 US 19870092953 20.06.1988 US 19880209104 (71) Applicant: WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Cambridge, MA 02142 (US)	(72) Inventors: KIM, Peter, S. Brookline, MA 02146 (US) OAS, Terrence, G. Watertown, MA 02172 (US) (74) Representative: Holdcroft, James Gerald, Dr.  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)