(19)

(11)

EP 0 377 031 A1

(12)

(43) Date of publication: 11.07.1990 Bulletin 1990/28 (21) Application number: 89907612.0 (22) Date of filing: 22.06.1989

(51) International Patent Classification (IPC):  C07D 213/ 84( . ) A61P 35/ 00( . ) C07D 471/ 04( . ) A61K 31/ 505( . ) C07D 213/ 85( . ) (86) International application number: PCT/US1989/002725 (87) International publication number: WO 1990/000172 (11.01.1990 Gazette 1990/02)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 01.07.1988 US 19880214510 (71) Applicant: Sloan-Kettering Institute For Cancer Research New York, New York 10021 (US)	(72) Inventors: WATANABE, Kyoichi, A. Rye-Brook, NY 10573 (US) SU, Tsann-Long Somers, NY 10589 (US) HUANG, Jai-Tung New Rochelle, NY 10801 (US) (74) Representative: Henkel, Feiler, Hänzel & Partner  Möhlstrasse 37 D-81675 München D-81675 München (DE)