(19)

(11)

EP 0 377 573 A1

(12)

(43) Date of publication: 18.07.1990 Bulletin 1990/29 (21) Application number: 88906000.0 (22) Date of filing: 21.07.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07H 21/ 04( . ) C12Q 1/ 68( . ) C07H 1/ 08( . ) C12N 15/ 10( . ) (86) International application number: PCT/GB1988/000591 (87) International publication number: WO 1989/000577 (26.01.1989 Gazette 1989/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 22.07.1987 GB 19870017280 14.06.1988 GB 19880014029 (71) Applicant: IMPERIAL CANCER RESEARCH TECHNOLOGY LIMITED London WC2A 3NL (GB)	(72) Inventors: STARK, George, Robert London WC2A 3PX (GB) MCINTYRE, Peter London E2 0JN (GB) (74) Representative: Cresswell, Thomas Anthony, et al  J.A. KEMP & CO. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)