(19)

(11)

EP 0 377 579 A1

(12)

(43) Date of publication: 18.07.1990 Bulletin 1990/29 (21) Application number: 88906510.0 (22) Date of filing: 06.07.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 25/ 00( . ) C07K 14/ 00( . ) C07K 14/ 47( . ) C07K 14/ 52( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) A61K 38/ 22( . ) A61P 25/ 28( . ) C07K 14/ 435( . ) C07K 14/ 50( . ) C12N 1/ 21( . ) C12N 15/ 85( . ) A61K 38/ 00( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1988/002264 (87) International publication number: WO 1989/000198 (12.01.1989 Gazette 1989/02)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 07.07.1987 US 19870070797 (71) Applicants: BIOTECHNOLOGY RESEARCH ASSOCIATES, J.V. Mountain View California 94043 (US) FIDDES, John C. Palo Alto, CA 94303 (US) ABRAHAM, Judith A. Sunnyvale, CA 94086 (US) PROTTER, Andrew Rush Cutter Bay, NSW 2011 (AU)	(72) Inventors: FIDDES, John, C.; Palo Alto, CA 94303 (US) ABRAHAM, Judith, A.; Sunnyvale, CA 94086 (US) PROTTER, Andrew; Rush Cutter Bay, NSW 2011 (AU) (74) Representative: Goldin, Douglas Michael, et al  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)