(19)

(11)

EP 0 378 533 A1

(12)

(43) Date of publication: 25.07.1990 Bulletin 1990/30 (21) Application number: 88904009.0 (22) Date of filing: 09.03.1988

(51) International Patent Classification (IPC):  A61K 38/ 09( . ) (86) International application number: PCT/US1988/000711 (87) International publication number: WO 1988/007056 (22.09.1988 Gazette 1988/21)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 10.03.1987 US 19870024205 (71) Applicant: Eastern Virginia Medical Authority Norfolk Virginia 23507 (US)	(72) Inventors: HODGEN, Gary, D. Norfolk, VA 23507 (US) KENIGSBERG, Daniel Stony Brook, NY 11794-8091 (US) (74) Representative: Wablat, Wolfgang, Dr.Dr.  Patentanwalt, Dr. Dr. W. Wablat, Potsdamer Chaussee 48 D-14129 Berlin D-14129 Berlin (DE)