(19)

(11)

EP 0 378 655 A1

(12)

(43) Date of publication: 25.07.1990 Bulletin 1990/30 (21) Application number: 89907914.0 (22) Date of filing: 23.06.1989

(51) International Patent Classification (IPC):  C07K 16/ 46( . ) A61K 38/ 00( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1989/002845 (87) International publication number: WO 1990/000616 (25.01.1990 Gazette 1990/03)

(84) Designated Contracting States: GB (30) Priority: 07.07.1988 US 19880216674 (71) Applicant: NEUMAIER, Michael Monrovia, CA 91016 (US)	(72) Inventor: NEUMAIER, Michael Monrovia, CA 91016 (US) (74) Representative: Sheard, Andrew Gregory  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)