(19)

(11)

EP 0 378 666 A1

(12)

(43) Date of publication: 25.07.1990 Bulletin 1990/30 (21) Application number: 89908361.0 (22) Date of filing: 05.07.1989

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 395( . ) C07H 21/ 04( . ) C07K 14/ 54( . ) C07K 16/ 00( . ) C12N 1/ 21( . ) C12P 21/ 02( . ) C12R 1/ 19( . ) A61K 38/ 00( . ) A61P 37/ 00( . ) C07K 14/ 52( . ) C07K 14/ 55( . ) C07K 19/ 00( . ) C12N 15/ 26( . ) C12P 21/ 08( . ) (86) International application number: PCT/US1989/002917 (87) International publication number: WO 1990/000565 (25.01.1990 Gazette 1990/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 05.07.1988 US 19880214998 (71) Applicant: AMGEN INC. Thousand Oaks, California 91320 (US)	(72) Inventors: ALTROCK, Bruce, W. Newbury Park, CA 91320 (US) BOONE, Thomas, C. Newbury Park, CA 91320 (US) GOLDMAN, Robert, A. Boulder, CO 80301 (US) KENNY, William, C. Thousand Oaks, CA 91360 (US) STABINSKY, Yitzhak 43 000 Raanana (IL) (74) Representative: Brown, John David, et al  FORRESTER & BOEHMERT Franz-Joseph-Strasse 38 D-80801 München D-80801 München (DE)