TUMOR NECROSIS ENHANCING FACTOR AND METHODS OF PREPARATION AND USE - Patent 0378676

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EP 0 378 676 A1

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(43)	Date of publication:
	25.07.1990 Bulletin 1990/30

(21)	Application number: 89908921.0

(22)	Date of filing: 14.07.1989

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International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 45/ 06^{( . )}
C07K 1/ 20^{( . )}
C07K 14/ 005^{( . )}
C07K 14/ 52^{( . )}
C12P 21/ 00^{( . )}

A61K 38/ 00^{( . )}
A61P 35/ 00^{( . )}
C07K 1/ 22^{( . )}
C07K 14/ 195^{( . )}
C07K 14/ 525^{( . )}
C12R 1/ 91^{( . )}

(86)	International application number:
	PCT/US1989/003108

(87)	International publication number:
	WO 1990/000400 (25.01.1990 Gazette 1990/03)

(84)	Designated Contracting States:
	AT BE CH DE FR GB IT LI LU NL SE

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Priority:

15.07.1988 US 19880219650

(71)	Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
	New York, New York 10027 (US)

(72)	Inventors:
	STERN, David, M. Lake Success, NY 11020 (US) NAWROTH, Peter D-6902 Sandhausen (DE)

(74)	Representative: Henkel, Feiler, Hänzel & Partner
	Möhlstrasse 37 D-81675 München D-81675 München (DE)

(54)	TUMOR NECROSIS ENHANCING FACTOR AND METHODS OF PREPARATION AND USE