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(11)

EP 0 380 508 A1

(12)

(43) Date of publication: 08.08.1990 Bulletin 1990/32 (21) Application number: 88907471.0 (22) Date of filing: 17.06.1988

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 11/ 00( . ) C12N 15/ 12( . ) C12N 15/ 85( . ) C12R 1/ 91( . ) C12N 9/ 64( . ) C12N 15/ 00( . ) C12N 15/ 58( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1988/002083 (87) International publication number: WO 1989/012685 (28.12.1989 Gazette 1989/30)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (71) Applicant: INTEGRATED GENETICS, INC. Framingham, MA 01701 (US)

(72) Inventors: WYDRO, Robert, M. Framingham, MA 01701 (US) OPPENHEIMER, Catherine, L. Milford, MA 01757 (US) BARNGROVER, Debra, A. Wayland, MA 01778 (US) FERRARA, Dawn, T. Lincoln, MA 01773 (US) DACKOWSKI, William, R. Hopkinton, MA 01748 (US) LANDES, Gregory, M. Northboro, MA 01532 (US) CAPALUCCI, Nancy, A. Ashland, MA 01721 (US) (74) Representative: Sheard, Andrew Gregory  Kilburn & Strode 30, John Street London WC1N 2DD London WC1N 2DD (GB)