(19)

(11)

EP 0 380 617 A1

(12)

(43) Date of publication: 08.08.1990 Bulletin 1990/32 (21) Application number: 89907995.0 (22) Date of filing: 19.06.1989

(51) International Patent Classification (IPC):  C12N 9/ 28( . ) C12R 1/ 10( . ) (86) International application number: PCT/US1989/002683 (87) International publication number: WO 1989/012679 (28.12.1989 Gazette 1989/30)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 21.06.1988 US 19880209426 (71) Applicant: Great Lakes Chemical Corporation West Lafayette, IN 47906 (US)	(72) Inventors: CHEN, James, C. Ashland, OH 44805 (US) LAMM, William, R. Ashland, OH 44805 (US) RACINE, Francis, M. Ashland, OH 44805 (US) TURNER, Hal, R. Ashland, OH 44805 (US) (74) Representative: Bond, Bentley George  HASELTINE LAKE & CO. Hazlitt House 28 Southampton Buildings Chancery Lane London, WC2A 1AT London, WC2A 1AT (GB)