(19)

(11)

EP 0 380 633 A1

(12)

(43) Date of publication: 08.08.1990 Bulletin 1990/32 (21) Application number: 89908630.0 (22) Date of filing: 10.07.1989

(51) International Patent Classification (IPC):  A61B 5/ 145( . ) A61B 5/ 1473( . ) A61B 5/ 1459( . ) G01N 33/ 487( . ) (86) International application number: PCT/US1989/003000 (87) International publication number: WO 1990/000365 (25.01.1990 Gazette 1990/03)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 11.07.1988 US 19880217612 (71) Applicant: EAST TENNESSEE STATE UNIVERSITY Johnson City, TN 37614-0002 (US)	(72) Inventor: ARBOGAST, Bradley, W. Johnson City, TN 37601 (US) (74) Representative: Watts, Peter Graham  Anthony Cundy & Co., 1623 Warwick Road Knowle, Solihull, West Midlands B93 9LF Knowle, Solihull, West Midlands B93 9LF (GB)