(19)

(11)

EP 0 381 701 A1

(12)

(43) Date of publication: 16.08.1990 Bulletin 1990/33 (21) Application number: 88909691.0 (22) Date of filing: 04.10.1988

(51) International Patent Classification (IPC):  C12N 11/ 18( . ) (86) International application number: PCT/US1988/003422 (87) International publication number: WO 1989/002920 (06.04.1989 Gazette 1989/08)

(84) Designated Contracting States: CH DE GB LI NL SE (30) Priority: 05.10.1987 US 19870105312 (71) Applicant: ARTHUR D. LITTLE, INC. Cambridge, Massachusetts 02140-2390 (US)	(72) Inventor: TAYLOR, Richard, F. West Boxford, MA 01885 (US) (74) Representative: Holdcroft, James Gerald, Dr., et al  Graham Watt & Co., Riverhead Sevenoaks, Kent TN13 2BN Sevenoaks, Kent TN13 2BN (GB)