(19)

(11)

EP 0 381 744 A1

(12)

(43) Date of publication: 16.08.1990 Bulletin 1990/33 (21) Application number: 89909601.0 (22) Date of filing: 09.08.1989

(51) International Patent Classification (IPC):  C12N 1/ 20( . ) C12N 9/ 88( . ) C12N 15/ 60( . ) C12R 1/ 19( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 13/ 22( . ) (86) International application number: PCT/GB1989/000907 (87) International publication number: WO 1990/001553 (22.02.1990 Gazette 1990/05)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 11.08.1988 GB 19880019135 (71) Applicant: CELLTECH LIMITED Slough Berkshire SL1 4EN (GB)	(72) Inventors: FROUD, Stephen, James Reading RG3 2UT (GB) LITTLE, Stephen, John Chester (GB) ROBINSON, Martyn, Kim Twickenham TW1 4SE (GB) LILLEY, Gerald Windsor SL4 4NR (GB) (74) Representative: Mercer, Christopher Paul, et al  Carpmaels & Ransford 43, Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)