(19)

(11)

EP 0 386 056 A1

(12)

(43) Date of publication: 12.09.1990 Bulletin 1990/37 (21) Application number: 88909521.0 (22) Date of filing: 24.10.1988

(51) International Patent Classification (IPC):  A61F 2/ 28( . ) A61L 24/ 00( . ) A61F 2/ 46( . ) (86) International application number: PCT/DK1988/000170 (87) International publication number: WO 1989/003695 (05.05.1989 Gazette 1989/10)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 23.10.1987 GB 19870024897 (71) Applicant: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK)	(72) Inventor: DOWNES, Sandra Herts. WD2 2AG (GB) (74) Representative: Sundien, Gunnar  HOFMAN-BANG & BOUTARD A/S Adelgade 15 DK-1304 Copenhagen K DK-1304 Copenhagen K (DK)