(19)

(11)

EP 0 386 059 A1

(12)

(43) Date of publication: 12.09.1990 Bulletin 1990/37 (21) Application number: 88909567.0 (22) Date of filing: 10.11.1988

(51) International Patent Classification (IPC):  C12N 15/ 02( . ) A61P 29/ 00( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) C07K 14/ 435( . ) C07K 16/ 28( . ) C12P 21/ 08( . ) C12R 1/ 91( . ) (86) International application number: PCT/GB1988/000977 (87) International publication number: WO 1989/004174 (18.05.1989 Gazette 1989/11)

(84) Designated Contracting States: AT BE CH DE FR GB IT LI LU NL SE (30) Priority: 10.11.1987 GB 19870026230 (71) Applicants: ROSEN, Hugh Cumnor, Oxford OX2 9QB (GB) GORDON, Siamon Oxford OX2 6LU (GB)	(72) Inventors: ROSEN, Hugh Cumnor, Oxford OX2 9QB (GB) GORDON, Siamon Oxford OX2 6LU (GB) (74) Representative: Hallybone, Huw George  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)